[fusion_builder_container admin_label=”” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” hundred_percent_height_center_content=”yes” equal_height_columns=”yes” menu_anchor=”multimaterial” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” status=”published” publish_date=”” class=”” id=”” link_color=”” link_hover_color=”” border_size=”” border_color=”” border_style=”solid” margin_top=”” margin_bottom=”0px” padding_top=”0px” padding_right=”” padding_bottom=”0px” padding_left=”” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”#f8f8f8″ background_image=”” background_position=”center center” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_mp4=”” video_webm=”” video_ogv=”” video_url=”” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” video_preview_image=”” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ spacing=”” center_content=”yes” link=”” target=”_self” min_height=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” background_image_id=”” hover_type=”none” border_size=”0″ border_color=”” border_style=”solid” border_position=”all” border_radius_top_left=”” border_radius_top_right=”” border_radius_bottom_right=”” border_radius_bottom_left=”” box_shadow=”no” box_shadow_vertical=”” box_shadow_horizontal=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0″ margin_bottom=”0″ background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ last=”no”][fusion_content_boxes layout=”timeline-vertical” columns=”1″ link_type=”” button_span=”” link_area=”” link_target=”” icon_align=”left” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_delay=”” animation_offset=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” title_size=”24″ heading_size=”1″ title_color=”#ffffff” body_color=”#fffefc” backgroundcolor=”#686868″ icon=”” iconflip=”” iconrotate=”” iconspin=”no” iconcolor=”” icon_circle=”” icon_circle_radius=”” circlecolor=”” circlebordersize=”” circlebordercolor=”” outercirclebordersize=”” outercirclebordercolor=”” icon_size=”” icon_hover_type=”” hover_accent_color=”#ffffff” image=”” image_id=”” image_max_width=”” margin_top=”0xp” margin_bottom=”0px”][fusion_content_box title=”Request for partners: Molecular imaging using spectral photon counting for Covid-19″ backgroundcolor=”” icon=”” iconflip=”” iconrotate=”” iconspin=”” iconcolor=”” circlecolor=”” circlebordersize=”” circlebordercolor=”” outercirclebordersize=”” outercirclebordercolor=”” image=”” image_id=”” image_max_width=”” link=”” linktext=”Read More” link_target=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=””]

MARS Bioimaging, New Zealand (MBI) is seeking for partners to better enable drug discovery and therapy monitoring for lung Covid-19 and other lung diseases. The disease is likely to continue to disrupt the world for at least 12-18 months. In addition, the work will have benefits for future pandemic response.

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What are the challenges faced in imaging lungs using CT today?

Covid-19, like other viral pneumonias, creates both lung inflammation and fibrosis. Current CT is non-specific and can only measure inflammation and fibrosis late in the disease, making diagnosis and treatment monitoring difficult. Therefore, MBI and its MARS partners around the world would like to use targeted nanoparticles to image lung inflammation. These can be either new nanoparticles or particles developed for inflammation elsewhere in the body.
Covid-19 infection also damages the heart. It has been observed that some patients who seemed to recover may die because of heart inflammation. Similarly to lung inflammation, nanoparticles could be used for heart imaging.

Current state:

MBI is in contact with nanoparticle developers who have previously developed a range of targeted nanoparticles. These groups believe they can make targeted nanoparticles for Covid-19 diseases in 2-6 months ready for the first animal testing. Nanoparticle administration could be through inhalation or injection or a combination.
MBI has access to a limited number of animal models for lung injury. Therefore work can begin immediately.
MBI has a network of spectral photon counting scanners in the USA and Asia-Pacific region. In the coming months it is expected that sites will become available in Europe. These scanners have a very high sensitivity and specificity for nanoparticles. These scanners have been used for molecular imaging in other areas such as bone, lung Tb, and cancer (see figures on the right of this page).

MBI is seeking partners who have:

Groups who have access to animal models of lung inflammation or models specific to Covid-19 infection
Groups who can synthesize nanoparticles to lung or heart injury in order to expand the number of nanoparticles available for testing.

Contact information

Prof Anthony Butler
MBChB DipGradSc FRANZCR PhD
Clinical radiologist and lead clinical researcher
anthony.butler@marsbioimaging.com

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The First Human Images from MARS

MARS scanners go beyond the traditional black-and-white CT to produce color images where different materials can be separated. In the images above, metal, soft tissue, fat and bone are all being identified. We have a commercial small bore scanner and are currently developing a human-scale machine.

FAQ

[/fusion_text][fusion_separator style_type=”none” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”” top_margin=”20″ bottom_margin=”” border_size=”” icon=”” icon_circle=”” icon_circle_color=”” width=”” alignment=”center” /][fusion_content_boxes layout=”icon-with-title” columns=”1″ title_size=”” title_color=”” body_color=”” backgroundcolor=”” icon=”” iconflip=”” iconrotate=”” iconspin=”no” iconcolor=”” icon_circle=”” icon_circle_radius=”” circlecolor=”” circlebordersize=”” circlebordercolor=”” outercirclebordersize=”” outercirclebordercolor=”” icon_size=”” icon_hover_type=”” hover_accent_color=”” image=”” image_width=”” image_height=”” link_type=”” link_area=”” link_target=”” icon_align=”left” animation_type=”” animation_delay=”” animation_offset=”” animation_direction=”left” animation_speed=”0.3″ margin_top=”” margin_bottom=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” image_max_width=””][fusion_content_box title=”What is color x-ray?” backgroundcolor=”” icon=”fa-question-circle far” iconflip=”” iconrotate=”” iconspin=”no” iconcolor=”” circlecolor=”” circlebordersize=”” circlebordercolor=”” outercirclebordersize=”” outercirclebordercolor=”” image=”” image_max_width=”” image_height=”” link=”” linktext=”Read More” link_target=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=””]

Color x-ray is where the energy (or color) of the x-rays that pass through the object is measured.

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Traditional x-ray measures the number of x-rays that have passed through, which gives information about the density of the object. Very dense materials don’t let many x-rays through, less dense objects let more through. Color x-ray can give information about which material an x-ray passed through rather than just its density. That means two objects of similar density but different materials can be distinguished.

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We use math algorithms to take the energy information from the color of the x-ray to find the materials present. We create separate image layers for each material. For example, one layer containing only bone, one containing only fat. X-rays don’t have colors that can be seen by the naked eye, so we apply a color (or color range) to each material. We can choose any color, but often we choose to use colors that look similar to what you would expect to see. We then take all the materials and combine them to produce a single color image.

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Color x-ray provides new diagnostic information. Traditional CT has poor soft tissue contrast, MRI is limited by its resolution. Color x-ray also offers opportunities to use next generation contrast agents such as gold nanoparticles to detect cancer.

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The video below shows how a MARS image is made up of multiple material layers. In this case, calcium, fat and soft tissue. It’s because of being able to measure the energy of the photons that the materials can be distinguished and quantified.

[/fusion_text][fusion_youtube id=”https://www.youtube.com/watch?v=2heoGBE7Qoc” alignment=”center” width=”” height=”” autoplay=”true” api_params=”&rel=0&autoplay=0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” /][fusion_separator style_type=”none” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”” top_margin=”20″ bottom_margin=”” border_size=”” icon=”” icon_circle=”” icon_circle_color=”” width=”” alignment=”center” /][fusion_button link=”http://www.marsbioimaging.com/mars/overview/” text_transform=”” title=”” target=”_self” link_attributes=”” alignment=”center” modal=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” color=”default” button_gradient_top_color=”” button_gradient_bottom_color=”” button_gradient_top_color_hover=”” button_gradient_bottom_color_hover=”” accent_color=”” accent_hover_color=”” type=”” bevel_color=”” border_width=”” size=”” stretch=”default” icon=”” icon_position=”left” icon_divider=”no” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” border_radius=””]Learn More[/fusion_button][/fusion_builder_column][fusion_builder_column type=”1_6″ layout=”1_6″ spacing=”” center_content=”no” link=”” target=”_self” min_height=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” hover_type=”none” border_size=”0″ border_color=”” border_style=”solid” border_position=”all” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”” margin_bottom=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” last=”no”][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_color=”” background_image=”” background_parallax=”fixed” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”no-repeat” background_position=”left top” video_url=”” video_aspect_ratio=”16:9″ video_webm=”” video_mp4=”” video_ogv=”” video_preview_image=”” overlay_color=”” video_mute=”yes” video_loop=”yes” fade=”no” border_size=”0px” border_color=”” border_style=”solid” padding_top=”0px” padding_bottom=”20px” padding_left=”5%” padding_right=”5%” hundred_percent=”no” equal_height_columns=”no” hide_on_mobile=”no” menu_anchor=”” class=”” id=””][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”no” hover_type=”none” link=”” border_position=”all”][fusion_text]

Create [fusion_popover title=”Measure with Confidence” title_bg_color=”” content=”The MARS scanner produces 3D image volumes scaled to the concentration of the target elements and compounds (mg/mL)” content_bg_color=”” bordercolor=”” textcolor=”” trigger=”hover” placement=”top” class=”” id=””]Quantitative[/fusion_popover] 3D Images with MARS

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circle_border_color=”#dc0614″ icon_rotate=”” icon_spin=”no” image=”” image_max_width=”35″ image_height=”35″ animation_type=”0″ animation_direction=”down” animation_speed=”0.1″]automatically produces a set of 3D image volumes containing each targeted element/compound (mg/mL) within minutes[/fusion_flip_box][fusion_flip_box title_front=”Imaging Tools” title_back=”Vision Workstation+zSpace” text_front=”visualize the color of x-rays” background_color_front=”#ffffff” title_front_color=”#3861aa” text_front_color=”#3861aa” background_color_back=”#0642fc” title_back_color=”” text_back_color=”” border_size=”1px” border_color=”” border_radius=”4px” icon=”fa-eye” icon_color=”#0642fc” circle=”yes” circle_color=”#34f2fc” circle_border_color=”#0642fc” icon_rotate=”” icon_spin=”no” image=”” image_max_width=”35″ image_height=”35″ animation_type=”0″ animation_direction=”down” animation_speed=”0.1″]interactive Virtual Reality system displays the element/compound 3D volumes for user-friendly sample evaluation and analysis[/fusion_flip_box][/fusion_flip_boxes][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”yes” overflow=”visible” margin_top=”5px” margin_bottom=”5px” background_color=”rgba(255,255,255,0)” padding_right=”20px” padding_left=”20px”][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”no” hover_type=”none” link=”” border_position=”all”][fusion_separator style_type=”none” sep_color=”” border_size=”” icon=”” icon_circle=”” icon_circle_color=”” width=”” alignment=”center” class=”” 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padding_right=”” padding_bottom=”” padding_left=”” margin_top=”10px” margin_bottom=”40px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ class=”” id=”” min_height=”” hover_type=”none” link=””][fusion_imageframe lightbox=”no” lightbox_image=”” style_type=”none” hover_type=”none” bordercolor=”” bordersize=”0px” borderradius=”0″ stylecolor=”” align=”center” link=”” linktarget=”_self” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ hide_on_mobile=”no” class=”” id=””] [/fusion_imageframe][/fusion_builder_column][fusion_builder_column type=”3_5″ layout=”3_5″ last=”yes” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_color=”” background_image=”” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_size=”0px” border_color=”” border_style=”” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”” margin_bottom=”” animation_type=”” animation_direction=”” animation_speed=”0.1″ 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Pre-clinical spectral scanner

[/fusion_title][fusion_checklist icon=”fa-chevron-right” iconcolor=”” circle=”” circlecolor=”” size=”14x” class=”” id=””][fusion_li_item icon=””]Medpix3 detectors bonded to high-Z sensors at 110 micron pitch with 8 energy bins per pixel and 2 ms frame readout[/fusion_li_item][fusion_li_item icon=””]120 kVp, 350 μA x-ray source with helical scan mode[/fusion_li_item][fusion_li_item icon=””]Precision horizontal in vivo sample stage with gas lines, monitoring inputs and temperature sensors[/fusion_li_item][fusion_li_item icon=””]Iterative reconstruction and processing algorithms quantify the concentration of elements and compounds in mg/mL[/fusion_li_item][fusion_li_item icon=””]Visualization workstation with HP Zvr 3D virtual reality display for image analysis[/fusion_li_item][/fusion_checklist][fusion_separator style_type=”none” top_margin=”10px” bottom_margin=”10px” sep_color=”” border_size=”” icon=”” icon_circle=”” icon_circle_color=”” width=”” alignment=”center” class=”” id=”” /][fusion_text columns=”” column_min_width=”” column_spacing=”” rule_style=”default” rule_size=”” rule_color=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=””]

Download the brochure

[/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_color=”” background_image=”http://www.marsbioimaging.com/mars/wp-content/uploads/2014/06/bkgd_bw2.jpg” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”no-repeat” background_position=”left top” video_url=”” video_aspect_ratio=”16:9″ video_webm=”” video_mp4=”” video_ogv=”” video_preview_image=”” overlay_color=”” video_mute=”yes” video_loop=”yes” fade=”no” border_size=”0px” border_color=”” border_style=”solid” padding_top=”50px” padding_bottom=”30px” padding_left=”5%” padding_right=”5%” hundred_percent=”no” equal_height_columns=”no” hide_on_mobile=”no” menu_anchor=”” class=”” id=””][fusion_builder_row][fusion_builder_column type=”2_5″ layout=”2_5″ last=”no” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_color=”” background_image=”” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_size=”0px” border_color=”” border_style=”solid” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ class=”” id=”” min_height=”” hover_type=”none” link=””][fusion_title margin_top=”” margin_bottom=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” size=”2″ content_align=”left” style_type=”double solid” sep_color=””]

Molecular imaging without radiotracers

[/fusion_title][fusion_separator style_type=”none” top_margin=”” bottom_margin=”8″ sep_color=”” border_size=”” icon=”” icon_circle=”” icon_circle_color=”” width=”” alignment=”center” class=”” id=”” /][fusion_text]

MARS promises to revolutionize diagnostic imaging by quantifying the elements and compounds of a sample in a single scan. It is the first commercially available 3D spectral (multi-energy) scanner to produce in vivo images with anatomic and molecular quantification at a fraction of the cost, time, and radiation dose of traditional molecular imaging, such as PET or SPECT.

The Medipix spectral x-ray detector technology was originally developed at CERN for the LHC and modified for medical applications; it is the result of 20+ years of collaborative innovation.

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Our customers

[/fusion_title][fusion_testimonials design=”clean” backgroundcolor=”” textcolor=”” random=”no” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=””][fusion_testimonial name=”Prof Ryan K. Roeder” avatar=”none” image=”” image_border_radius=”” company=”University of Notre Dame” link=”” target=”_self”]

My lab is pleased to feature the MARS photon-counting micro-CT in our research and development of targeted nanoparticle imaging probes for contrast-enhanced CT and quantitative molecular imaging with spectral (multi-energy) CT.

The MARS system is the only product on the market that enables my cutting-edge research to move forward as fast as possible. We are able to transition seamlessly between translation studies spanning from imaging phantoms to in vivo murine models.

[/fusion_testimonial][fusion_testimonial name=”Dr Aamir Younis Raja” avatar=”none” image=”” image_border_radius=”” company=”University of Otago, Christchurch” link=”” target=”_self”]

The MARS scanner in UOC has provided an opportunity to Christchurch researchers to be at the forefront of developing new clinical applications for photon counting CT modality.

By using this novel system, my research group has produced remarkable results on many aspects of the medical applications of spectral CT imaging such as molecular imaging of tumours, drug delivery, atherosclerosis and bone quality

[/fusion_testimonial][fusion_testimonial name=”Chair Professor Ge Wang” avatar=”none” image=”” image_border_radius=”” company=”Rensselaer Polytechnic Institute” link=”” target=”_self”]

My lab is blessed to have the latest MARS photon-counting micro-CT scanner. This spectral (multi-energy) CT will be used for preclinical research and development and translation to clinical applications such as targeted nanoparticle imaging and quantitative molecular imaging.

The MARS system is the only product in the market that enables important investigations with photon-counting detectors and redefines the state of the art.

[/fusion_testimonial][fusion_testimonial name=”Assoc Prof Steven Gieseg” avatar=”none” image=”” image_border_radius=”” company=”University of Canterbury, Christchurch” link=”” target=”_self”]

The MARS scanner gives us the ability to rapidly and non-destructively characterise atherosclerotic plaques at high resolutions.

Without this technology we would be unable to compare the biochemistry of the plaques and understand the effect of calcification on cell behaviour.

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