Lighting up tumour neovascularization using nanoparticles
A tumour was placed under the flank of the animal. Small gold nanoparticles (5 nm) were injected. The non-functionalized nanoparticles accumulate in areas of neovascularization (e.g. tumours) where vessels are more leaky.
Imaging specific binding of antibody-gold nanoparticle complexes in vitro
(a), (b), (c) calibration standards of gold chloride
(d) Ovarian cancer cells incubated with gold nano-particles targeted to a surface marker of ovarian cancer (Rituximab)
(e) Ovarian cancer cells with gold nano-particles targeted to breast cancer (Herceptin)